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. 2022 Nov 3;13:1001025. doi: 10.3389/fimmu.2022.1001025

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Copyright © 2022 Inciarte-Mundo, Frade-Sosa and Sanmartí

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calprotectin Functions. Intracellular functions are shown in orange and extracellular functions in green. Calprotectin Intracellular functions includes cytoskeleton cell migration and calcium homeostasis. Extracellular functions involve endothelial cells activation, promoting the adhesion of phagocytes to the vascular endothelium and thrombi formation. Also increase chemotaxis and the activation of PMN. Finally, calprotectin exerts a strong antimicrobial action against a variety of bacterial and fungal pathogens.