Figure 1.

Schematic representation of a CARM1-mediated asymmetric satellite cell division. The dystrophin glycoprotein complex (DGC) polarizes the cell, leading to divergent fates of the daughter cells (A) In the satellite cell undergoing activation, the dystrophin glycoprotein complex (DGC) is missing. This allows CARM1 to freely enter the nucleus, where is methylates PAX7. Methylated PAX7 then recruits the histone methyltransferase complex comprising of MLL1/2, ASH2L, WDR5, and RBBP5, leading to the induction of Myf5 transcription. (B) In the satellite stem cell, the presence of dystrophin leads to its interaction with p38γ. This results in heightened phosphorylation of p38γ and CARM1, leading to its sequestration to the cytoplasm, resulting in a reduction in Myf5 expression.