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. 2022 Sep 14;11(11):1143–1150. doi: 10.1093/stcltm/szac068

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — CARM1 regulation of pre-mRNA splicing. (A) Retention of introns 15 and 15 of Carm1 leads to the generation of a different form, called CARM1-v3. CARM1-v3 can interact with and methylate U1C, a member of the spliceosome complex. This favorably affects splicing of pre-mRNA. Moreover, CARM1 can methylate SmB and SAP49, other members of the spliceosome. (B) CARM1 contains an automethylation site on arginine 551. Mutating it to a lysine (R551K; methylation deficient) leads to a reduction in its ability to activate gene transcription of ERα target genes (TFF1 is shown as an example) or promote alternative splicing.