Table 3.

Enriched Gene Sets in Epithelial Cells Identified by GSEA Using Hallmark Gene Sets (Control vs Nqo1^Low)

Enriched in control (control vs Nqo1Low)
Gene set	NES	NOM P value	FDR q value
KRAS_SIGNALING_DN	1.73	<.001	.006

Enriched in Nqo1Low (Nqo1Low vs control)
Gene set	NES	NOM P value	FDR q value
INFLAMMATORY_RESPONSE	–1.97	<.001	<.001
ALLOGRAFT_REJECTION	–1.93	<.001	.001
E2F_TARGETS	–1.78	<.001	.002
KRAS_SIGNALING_UP	–1.75	<.001	.003
IL2_STAT5_SIGNALING	–1.66	<.001	.008
MTORC1_SIGNALING	–1.51	.003	.033
IL6_JAK_STAT3_SIGNALING	–1.47	.012	.045
ESTROGEN_RESPONSE_EARLY	–1.47	.001	.041
INTERFERON_GAMMA_RESPONSE	–1.46	.003	.037
COMPLEMENT	–1.46	<.001	.035
APICAL_SURFACE	–1.46	.026	.033
HEDGEHOG_SIGNALING	–1.43	.043	.037
TNFA_SIGNALING_VIA_NFKB	–1.37	.007	.068
G2M_CHECKPOINT	–1.35	.015	.080
ESTROGEN_RESPONSE_LATE	–1.29	.037	.117

FDR, false discovery rate.