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. Author manuscript; available in PMC: 2022 Nov 18.
Published in final edited form as: Nat Med. 2020 Aug 10;26(9):1468–1479. doi: 10.1038/s41591-020-1006-1

Extended Data Figure 2. Forced-directed layout of CD3+ populations at baseline in a) healthy donors and patients with newly diagnosed cHL and b) patients with newly diagnosed and relapsed/refractory cHL.

Extended Data Figure 2.

Each FDL shows expression of individual proteins ranging from no/low expression in blue to high expression in red. Clusters can be assigned a phenotype on the basis of these FDLs. Shown here are 12 proteins which allow identification of differentiation status (CCR7, CD45RO), polarization (CCR5, CCR4, CD161), activation (PD-1, T-bet, Eomes, Granzyme B), Tregs (FoxP3, CD25) and CXCR5+ cells.