Table 2.
Laboratorial tests assessed pre-treatment at D0, D113 in regular use of Theracurmin® 4 g every 12 h, D147 after 11 days washout, and D201 in regular use of Hydroxychloroquine 400 mg.
| Protocol day (D) | D1 | D113 | D147 | D201 |
|---|---|---|---|---|
| Serum creatinine (0.70–1.20 mg/dl) | 0.79 | 0.88 | 0.85 | 0.8 |
| Serum urea (13–43 mg/dl) | 18 | 22 | 27 | 25 |
| Urine density U (1003–1029) | 1,020 | 1,020 | 1,015 | 1,020 |
| Urine pH (4.50–7.80) | 6 | 6 | 6 | 5 |
| Urine leucocytes (0–7,000) | 0 | 1,000 | 1,000 | 1,000 |
| Urine red blood cells (0–3,000) | 0 | 1,000 | 0 | 500 |
| Urine protein/creatinine ratio (0.06–0.2 g/g) | 0.1 | 0.06 | NA | 0.07 |
| Urine albumin/creatinine ratio (<30 mg/g) | 9.2 | 6.58 | NA | 5.69 |
| Urine NGAL (0.40–72 ng/ml) | 7.61 | 6.69 | 2.19 | NA |
| C-reactive protein (<5 mg/dl) | 2.2 | 1.87 | 2.77 | 1.08 |
| White blood cell count (4,500–11,000/mm3) | 6,560 | 7,100 | 5,030 | 5,480 |
| Neutrophils (45,5–69,5%) | 47 | 67 | 50 | 44 |
| Lymphocytes (20,3–47%) | 32 | 17 | 27 | 32 |
| Monocytes (1,6–10%) | 15 | 11 | 15 | 13 |
| Eosinophils (0–4,4%) | 5 | 5 | 7 | 10 |
| Basophils (0,2–1,2%) | 1 | 0 | 1 | 1 |
| Haemoglobin (13.5–17.5 g/dl) | 14.6 | 14.3 | 13.2 | 14.2 |
| Platelet count (150–450×103/mcL) | 300 | 374 | 261 | 318 |
| Aspartate transaminase (15–40 U/L) | 16 | 15 | 29 | 17 |
| Alanine transaminase (10–40 U/L) | 18 | 21 | 29 | 15 |
| Bilirubin (<1 mg/dl) | 0.64 | 0.36 | 0.54 | 0.62 |
| Gamma-glutamyltransferase (2–30 U/L) | 22 | 20 | 18 | 16 |
| Cholesterol (<150 mg/dl) | 133 | 127 | 119 | 131 |
| Triglycerides (<100 mg/dl) | 91 | 107 | 86 | 62 |
| Serum total protein (6.0 a 8.0 g/dl) | 7.6 | 7.8 | 7.7 | 8.2 |
| Serum albumin (3.2 a 5.0 g/dl) | 3.9 | 3.9 | 4.1 | 4.4 |
| Serum globulin (0.7 a 1.5 g/dl) | 1.7 | 1.9 | 1.7 | 1.8 |
| C1q (100–250 mg/dl) | 389 | NA | NA | NA |
| C2 (14–25 mg/dl) | 14.1 | NA | NA | NA |
| C3 (67–149 mg/dl) | <4 | 5 | <4 | <4 |
| C4 (10–38 mg/dl) | 26.7 | 27.8 | 19.8 | 21.4 |
| HEp-2 ANA (non-reactive) | 1:1,280 | NA | NA | NA |
| Anti-double-stranded DNA (<1.0) | NR | NA | NA | NA |
| Anti-C1q (<9.0 U/ml) | 32 | NA | NA | NA |
| Anti-RNP (non-reactive—U/ml) | >200 | NA | NA | NA |
| Anti-Sm (non-reactive—U/ml) | 42.8 | NA | NA | NA |
| Anti-Ro/SSA (non-reactive—U/ml) | >200 | NA | NA | NA |
| Anti-La/SSB (non-reactive—U/ml) | 35.9 | NA | NA | NA |
| IgG anti-cardiolipin (<10 U GPL/ml) | 21.5 | NA | NA | NA |
| IgM anti-cardiolipin (<10 U MPL/ml) | 26.1 | NA | NA | NA |
| ANCA (non-reactive) | NR | NA | NA | NA |
| Anti-JO1 (non-reactive) | NR | NA | NA | NA |
| Anti SCL-70 (non-reactive) | NR | NA | NA | NA |
| Rheumatoid factor (<14 U/ml) | 219.2 | NA | NA | NA |
Normal values are indicated in parentheses. NR: non-reactive; NA: not available; NGAL: Neutrophil gelatinase-associated lipocalin; ANCA: Antineutrophil cytoplasmic antibodies; Anti-JO1: Anti-histidyl T-RNA synthetase; Anti SCL-70: Anti-topoisomerase I; HEp-2 ANA: Antinuclear antibodies on HEp-2 cells.