. 2022 Nov 13;58:102540. doi: 10.1016/j.redox.2022.102540

Table 4.

Effects of exogenous MT-GCH1 (C141A) on cognitive functions and MCA flow velocity in HTL-fed mice.

Groups	WT-GCH1	MT-GCH1	WT-GCH1+HTL	MT-GCH1+HTL
Swimming distance in quadrant (m)	2.87 ± 0.34	2.85 ± 0.52	1.39 ± 0.37^a	2.61 ± 0.42^b
Swimming distance out of quadrant (m)	2.98 ± 0.51	2.99 ± 0.55	4.57 ± 0.54^a	2.91 ± 0.46^b
Total swimming distance (m)	5.83 ± 0.82	5.90 ± 0.91	5.81 ± 0.89	5.79 ± 0.77
Swimming distance in quadrant/Swimming distance (Ratio)	0.49 ± 0.04	0.47 ± 0.07	0.24 ± 0.03^a	0.43 ± 0.05^b
Swimming time in quadrant (s)	23.16 ± 3.41	24.19 ± 3.01	12.53 ± 2.94^a	22.74 ± 3.29^b
Swimming time out of quadrant (s)	24.86 ± 4.07	25.61 ± 4.64	39.97 ± 5.09^a	24.15 ± 3.91^b
Swimming time in quadrant/Total swimming time (Ratio)	0.47 ± 0.12	0.49 ± 0.11	0.25 ± 0.08^a	0.49 ± 0.13^b
Latency (s)	22 ± 2.65	23 ± 2.88	37 ± 4.12^a	27 ± 3.01^b
Number of crossing platform	12.17 ± 1.49	13.01 ± 1.52	7.93 ± 0.93^a	10.29 ± 1.17^b
Swimming speed in quadrant (mm/s)	123.92 ± 26.77	117.81 ± 27.71	110.93 ± 18.45	114.78 ± 23.66
Swimming speed out quadrant (mm/s)	119.87 ± 23.31	116.75 ± 25.53	114.33 ± 23.68	120.49 ± 19.93
Average Swimming speed (mm/s)	121.49 ± 23.33	120.41 ± 26.53	111.73 ± 30.76	123.19 ± 26.17
MCA V_S (cm/s)	37.48 ± 5.16	35.67 ± 4.89	24.73 ± 4.25^a	34.57 ± 4.91^b
MCA V_d (cm/s)	23.29 ± 3.14	22.58 ± 3.70	14.71 ± 2.96^a	20.36 ± 3.43^b
PWV (cm/s)	249 ± 26	264 ± 30	705 ± 51^a	381 ± 34^b

The experimental protocols were described and graphical in Online Fig. S5A. The original recordings were presented Fig. 7A. Data are expressed as means ± SE. ^aP < 0.05 vs. WT-GCH1. ^bP < 0.05 vs. WT-GCH1 plus HTL. A one-way ANOVA followed by Scheffe test was used to determine P value between two groups in this table.