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. 2022 Nov 1;8(11):2242–2252. doi: 10.1021/acsinfecdis.2c00459

Table 2. Results of Checkerboard Assays with MRL-494 (1) and Rifampicin.

  MICa
 
  MRL-494 (1)
rifampicin
 
strain alone in combination alone in combination FICIb
E. coli ATCC 25922 16 1 2 0.13 0.125
E. coli BW25113 8 2 4 0.13 0.281
K. pneumoniae ATCC 13883 >128 2 8 0.25 ≤0.039
A. baumannii ATCC 9955 32 2 1 0.06 0.125
P. aeruginosa ATCC 27853 16 4 16 0.25 0.266
a

Minimum inhibitory concentration (μg/mL).

b

Synergy defined as FICI ≤0.5.