Table 2. Results of Checkerboard Assays with MRL-494 (1) and Rifampicin.
MICa |
|||||
---|---|---|---|---|---|
MRL-494 (1) |
rifampicin |
||||
strain | alone | in combination | alone | in combination | FICIb |
E. coli ATCC 25922 | 16 | 1 | 2 | 0.13 | 0.125 |
E. coli BW25113 | 8 | 2 | 4 | 0.13 | 0.281 |
K. pneumoniae ATCC 13883 | >128 | 2 | 8 | 0.25 | ≤0.039 |
A. baumannii ATCC 9955 | 32 | 2 | 1 | 0.06 | 0.125 |
P. aeruginosa ATCC 27853 | 16 | 4 | 16 | 0.25 | 0.266 |
Minimum inhibitory concentration (μg/mL).
Synergy defined as FICI ≤0.5.