Appendix Table 5.

Estimated hazard ratios of COVID-19 outcomes by NRTI combination in HIV-positive individuals,^* CoVIHd Collaboration, Spain, February-December 2020

	Documented SARS-CoV-2 infection	Hospitalization due to COVID-19	ICU admission due to COVID-19	COVID-19 death
	HR (95% CI)
TAF/FTC	1.00	1.00	1.00	1.00
TDF/FTC	1.08 (0.93, 1.21)	0.73 (0.47, 1.00)	0.40 (0, 1.26)	0.44 (0, 1.98)
ABC/3TC	1.21 (1.09, 1.33)	1.31 (1.03, 1.62)	1.51 (0.77, 3.18)	2.25 (1.09, 5.60)
Other regimes	1.05 (0.93, 1.18)	0.83 (0.63, 1.07)	0.75 (0.24, 1.83)	1.06 (0.41, 2.69)

^*Adjusted from Cox model with covariates age (in years, linear and quadratic terms), sex (male, female), transmission category (heterosexual, homo/bisexual, injecting drug use, other), country of origin (Spain, other), CD4 (<350, 350–500, >500 cells/mm3), and hypertension, diabetes, chronic renal disease, cardiovascular disease, and treatment with immunosuppressants or corticosteroids.