Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dynamic process of DNA methylation. In the diabetic environment, Dnmts and Tets are activated. Dnmts act at the 5′-position of cytosine residues in CpG islands to form 5mC and contribute to gene repression. Tets can quickly hydroxymethylate 5mC to 5hmC and promote gene activation. Dnmts, DNA methyltransferases; Tets, ten-eleven translocation dioxygenases; SAM, S-adenosyl methionine; 5mC, 5-methylcytosine; 5hmC, 5-hydroxymethylcytosine
