Table 3.

The subgroup analysis in PFS of patients with high TMB compared to low TMB

Subgroup	Number of study	Effects model	Pooled ES		Heterogeneity
			HR [95% CI]	P	I2	P-Value
Type of therapy
ICIs	4	Fixed	0.52[0.35,0.77]	< 0.001	50.3%	0.110
Non-ICIs	5	Random	2.31[0.89,5.97]	0.086	68.5%	0.013
Breast cancer subtype
HER2 +	4	Random	3.26[0.64,16.71]	0.156	74.2%	0.009
TNBC	4	Fixed	0.52[0.35,0.77]	0.001	50.3%	0.110
Sample source
tumor	5	Fixed	0.53[0.38,0.74]	< 0.001	35.4%	0.185
blood	4	Fixed	3.37[1.34,8.44]	0.01	38.1%	0.183
TMB detection method
NGS	8	Random	1.04[0.54,2.01]	0.909	83.4%	< 0.001
WES	1	-	0.63[0.28,1.14]	-	-	-
TMB cutoff value
≤ 5 Mut/Mb	4	Fixed	3.37[1.34,8.44]	0.01	38.1%	0.183
> 5 Mut/Mb	4	Fixed	0.52[0.35,0.77]	0.001	50.3%	0.110