Table 2.

Newcastle-Ottawa Scale for Non-Randomized Clinical Trials

Study	Selection (max 4•)	Comparability (max 2•)	Outcome (cohorts)/ Exposure (case-control) (max 3•)	Total score
DIANA-2	•••	•	•••	7
DIANA-5	••••	••	••	8
PACThe study	••	–	•••	5
WHEL study
Cohort	••••	••	•••	9
Case-control	••••	••	•••	9