Date	Event	Description
24 March 2020	New search has been performed	This systematic review has been updated with a new bibliographic search on 6 November 2019. Two promising studies have been labelled as 'awaiting classification' after failing in getting enough information to include or exclude them from the review. Random sequence generation in SPRINT 2015 has been considered as low risk of bias, after authors confirmation that they used a permuted block randomization scheme with random block lengths, stratified by clinic.
24 March 2020	New citation required but conclusions have not changed	The main conclusions remain unchanged after this update.
24 August 2018	Amended	The Risk of Bias figure and table have been amended to correct an error affecting the SPRINT study. As the main text correctly explained, this trial must be rated as 'unclear' in the random sequence generation domain. The 'allocation concealment' domain must be rated as 'low' risk of bias.
27 April 2018	New citation required and conclusions have changed	Four review authors included in the original version of the review (Muruzábal L, Malón MD, Montoya R, L￳ópez A) have not participated in this update, and two new contributors (Erviti J, Leache L) have now been included as review authors