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. 2022 Nov 18;4(4):lqac084. doi: 10.1093/nargab/lqac084

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© The Author(s) 2022. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Differences between ND and T2D interactome. (A) The presence/absence matrices report the presence and absence of the interactions (rows) in each cell type (columns) of the ND and T2D interactome. (B, C) The correlation matrices report the similarity between cell types of the ND and T2D interactome, in terms of spearman correlation between the interaction profiles, as-source (B) or as-target (C). The matrices are symmetrical and rows/columns have been clustered according to their similarities. The clustering results are indicated as dendrograms on the matrix margins. (D, E) The heatmaps report the changing interactions (rows) in each cell type (columns) in terms of spearman correlation between the interaction profiles, as-source (D) or as-target (E). The changing interaction profiles have been clustered according to their similarities, as indicated by the dendrograms on the top margins.