Table 1:
Representation of SLAAPs in protein sequences and their IDRs
| SLAAPa | Frequency in ISG/non-ISG productsb | Bias based on the frequency in human proteins | P- valuec | Conditional frequency in the IDRs of ISG/non-ISG products/background human proteinsc,d | P- valuee |
|---|---|---|---|---|---|
| SxNxE | 15.2%/8.8% | +47.6%/−14.2% | 1.5E-04 | 39.4%/40.3%/33.4% | 0.90 |
| ENE | 15.0%/8.8% | +20.9%/−29.0% | 2.1E-04 | 37.6%/42.9%/40.9% | 0.49 |
| SxNxT | 11.5%/6.2% | +21.9%/−34.2% | 2.9E-04 | 40.8%/25.9%/27.3% | 0.08 |
| SVI | 15.2%/9.2% | +37.6%/−16.9% | 3.6E-04 | 18.1%/11.3%/15.2% | 0.21 |
| LxNL | 23.7%/16.4% | +13.2%/−21.9% | 4.0E-04 | 10.2%/11.9%/9.4% | 0.65 |
| LxKL | 30.8%/22.8% | +18.0%/−12.8% | 4.9E-04 | 12.6%/10.1%/8.7% | 0.43 |
| NVT | 13.7%/8.5% | +52.1%/−6.1% | 1.2E-03 | 18.8%/21.6%/15.4% | 0.66 |
| ISS | 20.5%/14.3% | +20.7%/−15.7% | 1.7E-03 | 29.9%/25.6%/23.8% | 0.44 |
| LKxK | 24.4%/17.7% | +24.5%/−9.3% | 1.8E-03 | 14.6%/20.6%/20.0% | 0.16 |
| IKxE | 14.2%/9.0% | +34.2%/−14.5% | 1.8E-03 | 26.1%/16.5%/25.8% | 0.13 |
| EKxI | 15.8%/10.4% | +31.0%/−13.7% | 2.0E-03 | 15.3%/20.9%/16.0% | 0.32 |
| KxExS | 16.9%/11.4% | +21.9%/−17.7% | 2.4E-03 | 36.2%/36.0%/39.2% | 0.98 |
| LNS | 17.7%/12.1% | +21.2%/−17.1% | 2.4E-03 | 20.0%/25.5%/20.5% | 0.34 |
| KEN | 16.0%/10.6% | +33.5%/−11.0% | 2.4E-03 | 27.3%/41.9%/34.8% | 0.03 |
| LxNxL | 22.6%/17.5% | +14.3%/−11.4% | 1.5E-02 | 10.7%/11.8%/9.5% | 0.78 |
| KxExL | 25.8%/20.5% | +25.7%/−0.3% | 1.5E-02 | 18.8%/17.9%/18.7% | 0.84 |
| KLL | 27.1%/21.9% | +9.9%/−11.4% | 1.9E-02 | 11.3%/8.4%/9.9% | 0.35 |
| LKE | 29.8%/24.5% | +18.2%/−3.0% | 2.1E-02 | 19.5%/24.8%/20.1% | 0.20 |
| LKxL | 33.2%/27.7% | +15.0%/−4.2% | 2.1E-02 | 7.8%/12.4%/10.0% | 0.11 |
a
“x” in SLAAPs indicates 1 position occupied by a standard amino acid.
b
Here, the ISGs and non-ISGs are taken from dataset S2 while the background human genes use samples from dataset S1 (Table 5).
c
P-values in this column use Pearson's chi-squared tests to measure the difference of SLAAP occurrences in the ISG and non-ISG products.
d
Frequencies in this column are calculated based on a condition that corresponding SLAAPs are observed in the protein sequence.
e
P-values in this column use Pearson's chi-squared tests to measure the difference of SLAAP occurrences in the IDRs of the ISG and non-ISG products.