Figure 4.
Three tiered priority levels of conducting a P/vP assessment as part of the PMT/vPvM assessment presented in Figure 2. The Priority 1 tier is based on high-quality simulated half-lives, t1/2, compared to the relevant thresholds, or expert evaluations if available. The Priority 2 tier is based on inherent or readily biodegradable screening tests that can be used to screen for “Not P” or “Potential P/vP”. If no screening tests are available or the conclusion of them was “Potential P/vP”, then Priority 3 assessments are made using diverse weight-of-evidence indicators, including screening tests, QSARs, experience with removal during drinking water purification, and other evidence. SVHC-PBT = substances of very high concern because of its persistent, bioaccumulative and toxic properties or very persistent, very bioaccumulative properties as defined in the REACH regulation.