Figure 3. Inverse variance–weighted and Wald ratio Mendelian randomization results of genetically proxied lowering of tissue‐specific PCSK9 (proprotein convertase subtilisin/kexin type 9) gene expression on neuropsychiatric outcomes for men and women.

Estimates are reported odds ratios (ORs) and 95% CIs corresponding to a change in the risk for the neuropsychiatric end point for a change in genetically determined liver, whole blood, and brain PCSK9 gene expression (measured in transcripts per million [TPM]). Full results, including the combined‐sex results, are presented in Table S9.