Table 5.
Mediation Analysis of CKD Through AKI
| ß | Exp (ß) | 95% CI lower | 95% CI upper | P value | |
|---|---|---|---|---|---|
|
Any AKI CKD 4–5—eGFR <30 (mL/min per 1.73 m2) | |||||
| ACME (average) | 0.02276 | 1.02 | 0.00688 | 0.04 | 0.0024 |
| ADE (average) | 0.12788 | 1.14 | 0.06839 | 0.19 | <0.001 |
| Proportion of mediated (average) | 0.15107 | 0.04595 | 0.29 | 0.0024 | |
|
AKI stage 2 and 3 CKD 4–5—eGFR <30 (mL/min per 1.73 m2) | |||||
| ACME (average) | 0.03148 | 1.03 | 0.01086 | 0.05 | 0.0016 |
| ADE (average) | 0.12022 | 1.13 | 0.05968 | 0.18 | <0.001 |
| Proportion of mediated (average) | 0.20753 | 0.07058 | 0.4 | 0.0016 | |
|
Any AKI CKD 3–5—eGFR <30 (mL/min per 1.73 m2) | |||||
| ACME (average) | 0.01042 | 1.01 | 0.00317 | 0.02 | 0.0012 |
| ADE (average) | 0.08354 | 1.09 | 0.05065 | 0.12 | <0.001 |
| Proportion of mediated (average) | 0.11088 | 0.0334 | 0.2 | 0.0012 | |
ACME indicates average causal mediator effect; ADE, average direct effect; AKI, acute kidney injury; CKD, chronic kidney disease; and eGFR, estimated glomerular filtration rate.