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. 2022 Sep 29;11(19):e026581. doi: 10.1161/JAHA.122.026581

Figure 2. Mice lacking EP4R in kidney tubular epithelial cells maintain normal baseline BP and salt sensitivity.

Figure 2

The KEKOs have similar MAP measured by telemetry at baseline and during low‐ or high‐salt feeding (1 week respectively) compared with Controls (A). The BP changes from normal to low‐salt feeding and low‐ to high‐salt feeding periods were also similar between genotypes (B). Data are expressed as mean±SEM and analyzed by 2‐way ANOVA (factors: genotype and treatment) with Sidak multiple comparisons tests; n=9‐12/group; ^^^ P<0.001 vs Control LS (effect size: trivial); && P<0.01 vs KEKO baseline (effect size: trivial); ++ P<0.01 vs KEKO LS (effect size: trivial); BP indicates blood pressure; EP4R, E‐prostanoid receptor 4; HS, high salt; KEKO, kidney epithelial cell‐specific EP4 receptor knockout; LS, low salt; MAP, mean arterial pressure; and NS, normal salt.