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. 2022 Sep 29;11(19):e026581. doi: 10.1161/JAHA.122.026581

Figure 4. Kidney epithelial cells‐specific EP4R contributes to the regulation of sodium balance during Ang II infusion.

Figure 4

The sodium balance was calculated in Control and KEKO mice before and during the first 12 days of Ang II infusion. From day 7 to 12 of Ang II infusion, sodium balance was significantly higher in KEKOs. Data are expressed as mean±SEM and analyzed by 2‐way ANOVA (factors: genotype and days) with Sidak multiple comparisons tests; *P<0.05 vs Control at the same time point (effect size: large); n=7 to 8/group. Ang II indicates angiotensin II; EP4R, E‐prostanoid receptor 4; and KEKO, kidney epithelial cell‐specific EP4 receptor knockout.