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. 2022 Nov 16;38(1):203–215. doi: 10.1080/14756366.2022.2142786

Scheme 2.

Scheme 2.

Synthetic pathway for preparation of novel N-acyl amino acid conjugates 7a–m. Reagents and conditions: A = 4-aminobenzoic acid, isopropanol, heat, 16–18 h. B = 1,2,3 Benzotriazole, SOCI2, DCM, room temp. C = Amino acid, TEA, Acetonitrile, heat 70° C.