Table 3.

Pharmacokinetic Parameters in Rats Following Injection Administration of PTX-SLN@CUD and PTX

Parameter	Units	10 mg/kg
		PTX	PTX-SLN@CUD
AUC(0-t)	mg/L*h	2.381 ± 0.276	14.716 ± 1.985**
MRT(0-t)	h	4.94 ± 0.653	38.444 ± 2.983**
t1/2z	h	10.991 ± 0.773	44.293 ± 3.012**
Tmax	h	0.25 ± 0.02	0.61 ± 0.07**
Vz	L/kg	54.467 ± 8.532	37.46 ± 4.82**
CLz	L/h/kg	3.434 ± 0.312	0.443 ± 0.052**

Note: **P < 0.01 compared with PTX.

Abbreviations: AUC, area under concentration-time curve; t1/2z, half-life time; MRT, mean residence time; T_max, time to maximum plasma concentration; V_z, distribution volume; CLz, clearance.