Table 5.
Effects on Serum Biochemical Parameters of Mice After Intraperitoneal Administration in Different Experimental Groups
| Biochemical Indicators | Group B | Group C | Group D | Group E | Group F | Reference Range | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALT (U/L) | 80.4 | 69.7 | 73.5 | 51.1 | 63.8 | 47.1 | 46.8 | 107.5 | 113.2 | 83.6 | 60.7 | 79.1 | 66.4 | 74.8 | 50.8 | 33.0—98.7 |
| AST (mmol/L) | 2.68 | 6.04 | 3.55 | 5.42 | 4.82 | 6.04 | 4.42 | 8.33 | 6.06 | 4.78 | 7.94 | 6.23 | 2.69 | 5.04 | 3.43 | 2.00—7.70 |
| LDH (U/L) | 97.8 | 166.7 | 424.6 | 439.7 | 368.5 | 347.2 | 567.9 | 632.5 | 608.4 | 369.2 | 406.7 | 516.3 | 328.5 | 269.7 | 440.3 | 101.0—514.0 |
| UREA (μmol/L) | 30.9 | 49.7 | 45.8 | 58.2 | 99.2 | 73.6 | 112.1 | 93.5 | 126.0 | 48.0 | 78.8 | 56.7 | 46.2 | 57.0 | 81.6 | 22.0—97.0 |
| CREA (μmol/L) | 78.2 | 20.5 | 79.2 | 59.9 | 39.8 | 66.4 | 144.7 | 196.5 | 152.8 | 69.2 | 59.3 | 102.8 | 79.6 | 102.7 | 94.5 | 20.0—120.0 |
| UA (U/L) | 116.5 | 205.3 | 103.0 | 108.4 | 97.4 | 122.6 | 90.8 | 246.7 | 185.3 | 90.4 | 118.5 | 176.2 | 142.5 | 166.2 | 104.9 | 69.5—210.0 |
Notes: all mice in group A died after a single intraperitoneal administration, and the corresponding samples could not be collected. A Single Intraperitoneal Injection of PTX (A), PTX-SLN@CUD (B) at 40 mg/Kg and an Equal Volume of Saline (C). Intraperitoneal Injection Every Three Days for 60 Days: PTX (D), PTX-SLN@CUD (E) at 10 mg/Kg and an Equal Volume of Saline (F). (n=3).
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; CREA, creatinine; UA, uric acid.