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. 2020 Apr 22;138(1):40–46. doi: 10.1590/1516-3180.2019.0107.R2.16092019

Table 1. Minimum inhibitory concentration (MIC), mean fractional inhibitory concentration index (FICI) and interactions of simvastatin (SIM) and amphotericin B (AMB) and fluconazole (FLZ) against environmental strains of Cryptococcus neoformans.

Strain Minimum inhibitory concentration (MIC)

  • AMB

  • (µg/ml)

  • AMB + SIM

  • µg/ml)

  • SIM

  • (µg/ml)

  • SIM + AMB

  • (µg/ml)

  • FICI

  • (AMB + SIM)

 Interaction

  • FLZ

  • (µg/ml)

  • FLZ + SIM

  • (µg/ml)

  • SIM

  • (µg/ml)

  • SIM + FLZ

  • (µg/ml)

  • FICI

  • (SIM + FLZ)

 Interaction
Candida krusei ATCC 6258 1.0 N/A > 128 N/A N/A N/A 32 N/A > 128 N/A N/A N/A
PI1543 1.0 0.250 > 128 0.250 0.251 Synergism 8 64 > 128 > 128 9 Antagonism
PI1544 0.25 0.125 > 128 0.250 0.501 Indifferent 8 64 > 128 > 128 9 Antagonism
PI16167 0.5 0.125 > 128 0.250 0.251 Synergism 8 64 > 128 0.25 8 Antagonism
PI16180 1.0 0.500 > 128 0.250 0.501 Indifferent 4 32 > 128 > 128 9 Antagonism
PI16198 0.5 0.125 > 128 0.250 0.251 Synergism 8 64 > 128 > 128 9 Antagonism
PI16199 0.5 0.500 > 128 0.250 1.000 Indifferent 8 64 > 128 0.25 8 Antagonism
PI16200 0.5 0.250 > 128 0.250 0.501 Indifferent 8 64 > 128 > 128 9 Antagonism
PI16202 1.0 0.250 > 128 0.250 0.251 Synergism 8 8 > 128 1 1 Indifferent
PI17123 0.5 0.125 > 128 0.250 0.251 Synergism 8 64 > 128 > 128 9 Antagonism
PI17213 0.5 0.125 > 128 0.250 0.251 Synergism 8 64 > 128 > 128 9 Antagonism

N/A = not applicable; AMB = amphotericin B; SIM = simvastatin; FLZ = fluconazole; FICI = fractional inhibitory concentration index.