Table 5. Devices and products for use against COVID-19 identified in registered clinical trials.
| Devices/products | Number of trials | Remarks |
|---|---|---|
| Web application | 1 | Used to assess the evolution of the number of calls to the emergency service within 12 days after the launch of the application.14 |
| Hyperbaric oxygen therapy (HBOT) device | 1 | This delivers pure oxygen in a pressurized room or tube.14 |
| GO2 PEEP mouthpiece | 2 | This effectively delivers PEEP with every breath of patients.14 |
| Oxyhydrogen device | 1 | Used to improve symptoms of patients with COVID-19.14 |
| Oxygen monitoring device | 1 | Used for monitoring peripheral blood oxygen saturation and oxygen concentration.14 |
| CT-V | 1 | Used to detect parenchymal lung function changes at a voxel level.14 |
| vv-ECMO + cytokine adsorption (CytoSorb adsorber) | 1 | This combination can lead to reduction of the levels of circulating pro and anti-inflammatory cytokines.14 |
| vv-ECMO only (no cytokine adsorption) | 1 | This provides support for the lungs. It is used in situations of acute respiratory failure in COVID-19-disease.14 |
| VivaDiag* COVID-19 lgM/IgG | 1 | This is used to evaluate the immune response of negative patients during the outbreak of COVID-19.14 |
| A mindfulness meditation mobile app - Calm v4.22 | 1 | This app includes meditation lessons, sleep stories (bedtime stories for grown-ups), sleep music and nature sounds.14 |
| Medical/surgical mask | 2 | This is a loose-fitting disposable device for creating a physical barrier. |
| N95 respirator | 1 | This is a respiratory protective device. |
| High-flow nasal cannula (HFNC) | 1 | This is a device that can deliver 100% humidified and heated oxygen. |
| Inspiratory training device | 1 | This is a device that is used to determine the effectiveness and safety of respiratory training in relation to preventing and reducing the severity of COVID-19.14 |
| Expiratory training | 1 | This tends to improve coughing and reduce the sensation of respiratory effort.32 |
| Cordio app v1.54 | 1 | This app uploads vocal data to the sponsor’s servers for analysis.14 |
| Biosensors | 1 | These detect changes in respiration, temperature and circulation.14 |
| SensiumVitals** wearable sensor | 1 | This sensor measures heart rate, respiratory rate, temperature and suspected coronavirus in a designated location (e.g. a hotel).14 |
| CVVH machine | 1 | This has the aim of clearing CO2 and improve oxygenation.14 |
| MAGEC spine rod*** | 1 | Magnetically controlled spine rod for treatment of scoliosis.14 |
| Transpulmonary thermodilution | 1 | Transpulmonary thermodilution is a technique that provides a full hemodynamic assessment.33 |
| Echocardiography | 1 | Echocardiography is a test that uses sound waves to produce live images of the heart. |
| TAVR or SAVR | 1 | Used to describe rates of morbidity and mortality.14 |
| CPAP treatment device | 1 | CPAP is a common treatment for obstructive sleep apnea. |
| Home blood pressure monitoring device - Qardio Arm (Qardio, California, United States) | 1 | Home blood pressure device with telemonitoring capability that allow participants and their physicians to monitor blood pressure over time and to titrate blood pressure medications as needed for persistently elevated blood pressure.14 |
| Automated oxygen administration - FreeO2 device (OxyNov Inc, Quebec, Canada) | 1 | This provides a solution for reducing the number of interventions by healthcare workers relating to oxygen therapy, so as to reduce complications relating to oxygen and improve monitoring.14 |
| CELLECTRAÂ**** 2000 | 1 | This is applied to increase the permeability of cell membranes to enhance the uptake of drugs or vaccines into target cells.34 |
| Caption AI | 1 | Software program to take the best possible pictures of the heart.14 |
| Stem Cell Educator-Treated Mononuclear Cell Apheresis (Tianhe Stem Cell Biotechnologies Inc, Shandong, China) | 1 | This circulates a patient’s blood through a blood cell separator, briefly cocultures the patient’s immune cells with adherent CB-SC in vitro, and returns the “educated” autologous immune cells to the patient’s circulation.14 |
| COVID-19 Symptom Tracker app v0.3 | 1 | This records and monitors the symptoms of COVID-19 coronavirus infection; tracking in real time how the disease progresses.14 |
PEEP = positive end-expiratory pressure; CT = computed tomography; vv-ECMO = veno-venous extracorporeal membrane oxygenation; IgM = immunoglobulin M; IgG = immunoglobulin G; COPD = chronic obstructive pulmonary disease; CVVH = continuous veno-venous hemofiltration; NCP = novel coronavirus pneumonia; TAVR = transcatheter aortic valve replacement; SAVR = surgical aortic valve replacement; AI = artificial intelligence; CB-SC = cord blood stem cells.
*Everest Links Pte Ltd, Midview City, Singapore; **Sensium Healthcare Ltd, Oxford, United Kingdom; ***NuVasive, California, United States; ****Inovio Pharmaceuticals, Pennsylvania, United States.