Table 2.

Geometric means of responses and fold reduction in paired samples of Omicron responder subsets.

Paired responders in sample cohort (n; [% of total n per vaccination scheme])	GMT (95% CI) of paired responders across indicated variants
	B.1	Beta B.1.351	Delta B.1.617.2	Omicron BA.1
One-dose Ad26.CoV2.S * (1; [4.4])	na	na	na	na
Two-dose AZD1222 (14; [56.0])	155.80 (96.60–251.20)	40.98 (23.66–70.97)	83.52 (49.68–140.40)	14.39 (8.92–23.23)
First dose AZD1222, second dose BNT162b2 (21; [84.0])	791.90 (558.90–1122.00)	132.0 (87.94–198.00)	469.50 (316.00–697.50)	49.72 (34.00–72.71)
First dose AZD1222, second dose mRNA-1273 (21; [87.5])	1098.00 (793.80–1518.00)	284.20 (183.20–440.90)	760.70 (513.60–1127.00)	78.68 (54.36–113.90)
Two-dose mRNA-1273 (24; [100.0])	453.80 (351.2–586.4)	85.48 (55.45–131.80)	393.50 (284.4–544.4)	29.50 (21.58–40.33)
Two-dose BNT162b2 T1 (11; [47.8]) **	406.80 (300.90–550.00)	54.41 (32.19–91.99)	371.00 (243.30–565.50)	18.21 (11.83–28.03)
Two-dose BNT162b2 T2 (13; [56.2]) **	98.77 (68.41–142.60)	33.07 (21.25–51.45)	82.63 (53.60–127.4)	14.22 (9.74–20.75)

Paired responders in sample cohort (n; [% of total n per vaccination scheme])	Fold reduction in GMT of paired responders across indicated variants
	B.1	Beta B.1.351	Delta B.1.617.2	Omicron BA.1
One-dose Ad26.CoV2.S * (1; [4.4])	–	na	na	na
Two-dose AZD1222 (14; [56.0])	–	3.80	1.87	10.83
First dose AZD1222, second dose BNT162b2 (21; [84.0])	–	6.00	1.69	15.93
First dose AZD1222, second dose mRNA-1273 (21; [87.5])	–	3.86	1.44	13.96
Two-dose mRNA-1273 (24; [100.0])	–	5.31	1.15	15.38
Two-dose BNT162b2 T1 (11; [47.8]) **	–	7.48	1.10	22.34
Two-dose BNT162b2 T2 (13; [56.2]) **	–	2.99	1.20	6.95

*Only one individual showed detectable neutralization titers in the Omicron BA.1 assay.

**Two-dose BNT162b2 T1 and two-dose BNT162b2 T2 are paired longitudinal samples.