TABLE 2.

Correlation coefficients of serum differential metabolites between different paired comparison groups.

Metabolites	FC
	Model 1 vs. control	Model 2 vs. control	LP vs. control	HP vs. control
3-Hydroxybutyrate	–0.32961	–0.52644	–0.27046
Acetate	+ 0.3388			+ 0.6747
Alanine	+ 0.29435	+ 0.2173	+ 0.51014
Choline		+ 0.44545
Glutamate				+ 0.69206
Glycine	–0.33434	–0.48691
Isobutyrate	+ 0.75203	+ 1.2462
Lactate	+ 0.60182	+ 0.83173	+ 0.90002	+ 0.4537
Lysine	+ 0.53865
N-acetylglucosamine				–0.58918
Phenylalanine		+ 1.3653		+ 0.97413
Pyruvate			+ 0.90236
Tyrosine				+ 0.65458

FC (fold change) indicates the fold change of metabolites between two groups as the logarithmic value of the mean ratio between two groups with a base of 2; + and − indicate the increase or decrease of metabolite concentration in the previous group, respectively.