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. 2022 Mar 24;18(12):2817–2829. doi: 10.1080/15548627.2022.2048432

Figure 3.

Figure 3.

Tet2 knockdown alters the gene expression profiles of osteoclasts and reduces autophagic vesicle formation by increasing BCL2 expression. (A) Volcano plots of all differentially expressed genes (>1.5-fold) in LV-NC- and LV-shTet2-transfected BMs after stimulation with TNFSF11 for 3 days. (B) Heatmaps of all differentially expressed genes (>1.5-fold) in LV-NC- and LV-shTet2-transfected BMs after stimulation with TNFSF11 for 3 days were shown; red represented higher expression, and blue represented lower expression. (C) The expression of BCL2 in LV-NC and LV-shTet2 BMs during osteoclast differentiation was analyzed by western blot analysis. (D) The western blot results were quantified. The data are expressed as the means ± SEM (* P < 0.05, ** P < 0.01, n = 3, three biological duplications).