Fig. 1.

The power curves represent the total sample size required to detect an absolute difference of 7% in the proportion of parents achieving a modified Rankin (mRS) score of 0 or 1 by three-months after stroke between the hypothermia and normothermia treatment groups. Sample sizes were calculated over a range of expected outcome rates in the normothermia group and power. Power analysis was conducted using a two-sided binomial test of proportions with a normal approximation and an overall Type I error rate of 5%. mRS, Modified Rankin Scale score.