Table 1. Clinical and CMR characteristics in patients with non-ischemic cardiomyopathy vs the control cohort.
| Preserved LVEF (N = 58) | NICM (N = 41) | P-value | ||
|---|---|---|---|---|
| Clinical Characteristics | ||||
| Age (years) | 51 ± 13 | 51 ± 14 | 0.95 | |
| Gender, N (% male) | 18 (31%) | 24 (59%) | 0.006 | |
| Ethnicity | White, N (%) | 52 (90%) | 28 (68%) | 0.02 |
| Black, N (%) | 4 (7%) | 12 (29%) | ||
| Hispanic, N (%) | 1 (2%) | 0 (0%) | ||
| Other, N (%) | 1 (2%) | 1 (3%) | ||
| Diabetes, N (%) | 7 (12%) | 6 (15%) | 0.77 | |
| Hypertension, N (%) | 25 (43%) | 24 (59%) | 0.16 | |
| Hyperlipidemia, N (%) | 21 (36%) | 16 (39%) | 0.83 | |
| Atrial Fibrillation/Flutter, N (%) | 9 (16%) | 3 (7%) | 0.35 | |
| Creatinine (mg/dL) | 0.90 ± 0.35 | 0.93 ± 0.23 | 0.32 | |
| Hematocrit (%) | 39±6 | 38±6 | 0.68 | |
| B-type Natriuretic Peptide (ng/L) | 63 (29–202) | 78 (39–991) | 0.39 | |
| Troponin-I (ng/mL) | 0.01 (0.01–0.02) | 0.01 (0.0–0.05) | 0.17 | |
| CMR Characteristics | ||||
| LVEDD (cm) | 4.7 (4.4–5.1) | 5.6 (5.3–6.3) | <0.001 | |
| LVEDV (mL) | 122 (106–142) | 184 (154–217) | <0.001 | |
| LVEDV Indexed (mL/m2) | 63 (58–75) | 97 (70–107) | <0.001 | |
| LVESV (mL) | 45 (37–53) | 107 (83–144) | <0.001 | |
| LVESV Indexed (mL/m2) | 22.8 (20.0–28.0) | 55.2 (41.4–68.6) | <0.001 | |
| LVEF (%) | 64 ± 6 | 42 (32–45) | <0.001 | |
| LA Volume Indexed (gm/m2) | 39 (30–48) | 45 (40–59) | 0.001 | |
| LV mass (gm) | 83 (64–102) | 110 (86–130) | <0.001 | |
| LV mass Indexed (gm/m2) | 40.8 (35.3–48.9) | 55.2 (46.3–63.7) | <0.001 | |
| LGE presence (%) | 9 (16) | 21 (51) | < 0.001 | |
| Number of segments | 2 (1–3) | 3 (2–4) | 0.16 | |
| Myocardial Perfusion Slope (rest) | 4.9 (4.1–7.0) | 3.9 (3.2–5.3) | 0.045 | |
| Myocardial Perfusion Slope (stress) | 11.7 (8.8–16.0) | 8.8 (6.1–10.5) | <0.001 | |
| Myocardial Perfusion Reserve Index | 1.74 (1.51–2.09) | 1.41 (1.19–1.93) | 0.02 | |
LV: left ventricle; EDD: end diastolic dimension; EDV: end diastolic volume; EF: ejection fraction; ESV: end systolic volume; LA: left atrium; LGE: late gadolinium enhancement.