TABLE 1.
Effect of an anti-TNF monoclonal antibody on LAM-induced chemokine productiona
| Chemokine | Mean level ± SE (ng/ml) of:
|
% Inhibition | |
|---|---|---|---|
| LAM + IgG | LAM + anti-TNF | ||
| IL-8 | 12.93 ± 4.21 | 0.12 ± 0.91* | 92 ± 3 |
| MCP-1 | 11.26 ± 12.54 | 2.28 ± 0.64* | 81 ± 4 |
| MIP-1β | 18.47 ± 29.73 | 3.91 ± 0.80* | 76 ± 6 |
a
Data from six different HIV-seronegative donors. Whole blood diluted 1:1 in RPMI medium was incubated for 16 h at 37°C with LAM (1 μg/ml) and anti-human TNF or control IgG (both 10 μg/ml). *, P < 0.05 (versus LAM + IgG).