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. 2022 Nov 18;8(46):eadd2288. doi: 10.1126/sciadv.add2288

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Fig. 5. — (A) Experimental protocol of survival study (control, n = 9; high H3, n = 9). (B) Acoustic emissions for all survival mice. (C) T2-weighted MR images throughout treatments and survival monitoring. One animal (shown as FUS + PD1) survived and had its tumor cured and was rechallenged at day 70. Rechallenged animal did not express any endpoint criteria after 28 days. (D) Kaplan-Meier survival analysis between control group and high H3 group. Significant improvement in survival was observed between sonicated group and control group (P < 0.05). (E) Flow cytometry plot showing CD4⁺ and CD8⁺ lymphocytes (gated on CD45⁺CD11b⁻) in the rechallenged brain. (F) Flow cytometry plot showing CD69 and CD103 expression (gated on CD45⁺CD11b⁻CD8⁺) on CD8 T cells in the rechallenged brain (black) and blood (red). (G) Quantification of total CD69⁺CD103⁺CD8 T cells in the rechallenged brain and blood.