Fig. 2. Integrated multi-omics molecular predictions of progressive cognitive and neuropathological deterioration.

(A to F) Postmortem brain-based molecular disease progression predictions (ROSMAP data) of tau neurofibrillary tangles (A), neuritic plaques (B), TDP-43 cytoplasmatic inclusions in neurons and glia (C), arteriolosclerosis stages (D), presence of neocortical Lewy bodies (E), and hippocampal sclerosis (F). All P values are FWE-corrected via randomized permutation tests. (G) Nonredundant associations with neuropathological phenotypes (i.e., LASSO regression results, with 10-fold cross-validation, and adjusted by age, sex, and educational level).