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. 2022 Nov 18;11:e82094. doi: 10.7554/eLife.82094

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© 2022, Möller et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — (A) Microglia (red; Tg(csf1ra:GAL4-VP16; UAS:lyn-tagRFPt)) overexpressing the centrosome marker (cyan; Tg(UAS:miRFP670-cetn4)). Due to mosaicism in the overexpression of UAS:miRFP670-cetn4, there are microglia (dashed outlines) with two centrosomes (orange cells) and matching controls with only one (blue cells) within the same brain. Centrosomes are labelled with circles. (B) Microglia (grey) overexpressing the centrosome marker (cyan) resulting in this cell having two centrosomes (circle). (C) Microglia with two centrosomes engulf more neurons (N = 8, 2–9 microglia analysed per fish). Boxplots depict mean +/- min and max values. Groups were compared using a two-tailed, nonparametric Mann-Whitney U test, ****p<0.0001. N refers to the number of zebrafish analysed.

Figure 7—source data 1. Related to Figure 7C.

elife-82094-fig7-data1.xlsx^{(17.6KB, xlsx)}