Figure 5. The IFT-A 3D model is highly concordant with literature evidence not used in modeling.

Panels I-XII highlight specific IFT-A intermolecular interactions, both at the protein and domain level, known from the literature (see the text for detailed discussion and citations). The interacting proteins or domains form direct contacts within the IFT-A model in all cases examined. Support for the interactions was observed across organisms, consistent with high conservation of the IFT-A complex across species. IP, immunoprecipitation; Y2H, yeast 2-hybrid; KO, knockout mutant. Proteins are colored as in Figure 4.