Table 3.

Cox Proportional Hazards Regression: Transition-Specific Estimates for Covariates From the Semi-parametric Cox Proportional Hazards Regression

	Transition 1: Admission to Cardiovascular Complication		Transition 2: Admission to Died		Transition 3: Cardiovascular Complication to Died		Transition 4: Cardiovascular Complication to Home Discharge		Transition 5: Admission to Home Discharge
	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI	HR	95% CI
Age ≥ 65 y	1.34	1.03-1.75			0.80	0.54-1.19
Male	1.32	1.03-1.68	1.00	0.72-1.39	0.98	0.66-1.45	0.85	0.58-1.25	1.06	0.93-1.20
Smoking history	1.02	0.81-1.3			1.41	0.96-2.06	0.72	0.49-1.06	0.85	0.75-0.96
Obese	1.06	0.83-1.35	0.85	0.61-1.18	1.28	0.88-1.88			0.94	0.83-1.07
Diabetes	1.09	0.85-1.4	1.13	0.82-1.58	0.92	0.62-1.38	0.91	0.61-1.37	1.02	0.89-1.17
Renal disease	1.14	0.86-1.51	1.46	1.00a-2.13	0.64	0.40-1.02			1.01	0.85-1.21
Congestive heart failure	1.59	1.18-2.15	1.06	0.68-1.64	1.46	0.94-2.29	1.18	0.71-1.98
Aspirin use	1.08	0.83-1.40	0.72	0.51-1.03	0.87	0.59-1.29	0.97	0.65-1.44	0.95	0.82-1.11
Coronary artery disease	1.34	1.00-1.79	1.17	0.78-1.76	1.17	0.76-1.80	1.21	0.77-1.91	1.01	0.84-1.20
Hypertension	1.07	0.79-1.44	1.04	0.71-1.52	1.4	0.87-2.26	0.89	0.57-1.39	0.97	0.84-1.11
Hyperlipidemia	1.09	0.84-1.41	0.83	0.59-1.17	1.03	0.68-1.56	0.97	0.64-1.47	0.97	0.84-1.11
Atrial fibrillation	1.43	1.06-1.95	0.92	0.59-1.43	1.15	0.72-1.83	1.06	0.66-1.71	0.89	0.71-1.13
Cerebrovascular disease	1.08	0.78-1.49	1.67	1.12-2.48	1.11	0.69-1.78	1.13	0.67-1.89	0.79	0.64-0.98
Direct admission to ICU	1.77	1.36-2.32	1.80	1.26-2.55	1.56	1.00a-2.43
Elevated ferritin (> 500 ng/mL)	1.07	0.84-1.37	0.98	0.71-1.37	0.80	0.54-1.18	0.75	0.50-1.13
Low Pao2/Fio2 (< 200)	1.46	1.11-1.92			1.00	0.63-1.56	0.49	0.30-0.83

Empty cells indicate violations to the proportional hazard’s assumption. Cells with bolded text indicate statistical significance. HR = hazard ratio.

^aCI lower bound was < 1 but appears as 1.00 due to rounding.