Table 2.

Differences in total overdose deaths, total overdose deaths without methadone, and methadone-involved overdose deaths between the 12-month periods before and after March 2020.

	Total overdose deaths	Total overdose deaths without methadone	Methadone-involved overdose deaths	p-value
All	24,678 (33.9 %)	23,611 (33.7 %)	1067 (39.1 %)	< 0.001
Gender
Female	6474 (27.8 %)	6097 (27.5 %)	377 (32.6 %)	< 0.001
Male	18,204 (36.8 %)	17,514 (36.5 %)	690 (43.9 %)	< 0.001
Race/ethnicity
Hispanic	3677 (47 %)	3482 (46.1 %)	195 (70.4 %)	< 0.001
Non-Hispanic Black	5480 (49.7 %)	5271 (49.4 %)	209 (57.1 %)	< 0.001
Non-Hispanic White	14,237 (27.7 %)	13,610 (27.6 %)	627 (31.4 %)	< 0.001
Other	1277 (48.9 %)	1241 (49.1 %)	36 (41.9 %)	0.015
With synthetic opioid involvement	23,345 (60.7 %)	22,631 (60.5 %)	714 (71.4 %)	< 0.001
Sex
Female	6193 (58.2 %)	5971 (58.1 %)	222 (60.7 %)	< 0.001
Male	17,152 (61.7 %)	16,660 (61.4 %)	492 (77.6 %)	< 0.001
Race/ethnicity
Hispanic	3203 (77.9 %)	3087 (77.2 %)	116 (101.8 %)	< 0.001
Non-Hispanic Black	4833 (74.2 %)	4673 (74.2 %)	160 (75.8 %)	< 0.001
Non-Hispanic White	14,200 (53.1 %)	13,796 (52.9 %)	404 (62.1 %)	< 0.001
Other	1109 (104.9 %)	–	–	–
Without synthetic opioid involvement	1333 (3.9 %)	980 (3 %)	353 (20.4 %)	< 0.001
Sex
Female	281 (2.2 %)	126 (1.1 %)	155 (19.6 %)	< 0.001
Male	1052 (4.8 %)	854 (4.1 %)	198 (21.1 %)	< 0.001
Race/ethnicity
Hispanic	474 (12.8 %)	395 (11.1 %)	79 (48.5 %)	< 0.001
Non-Hispanic Black	647 (14.3 %)	598 (13.7 %)	49 (31.6 %)	0.01
Non-Hispanic White	37 (0.2 %)	-186 (−0.8 %)	223 (16.5 %)	< 0.001
Other	168 (10.8 %)	–	–	–

Relative percentage increases from the 12 months before March 2020 to the 12 months after March 2020 are shown in parentheses. P-values compare counts of methadone-involved overdose deaths between the two 12-month periods. P-values are calculated using z-tests. Omitted data could not be displayed due to data suppression rules.