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Recombinant IL-27 elevated the generation of Foxp3+ and LAP+ Tregs in the spleen of ApoE−/− mice. (a) In the spleen, the fractions of Foxp3+ and LAP+ Tregs were measured by flow cytometry. (a) and (b) show the fractions of Foxp3+ Tregs (A) and LAP+ Tregs (B) during the initiation of atherosclerosis. (C) and (D) show the fractions of Foxp3+ Tregs (C) and LAP+ Tregs (D) during the progression of atherosclerosis. (b) Groups data are shown in histogram. ∗∗∗P < 0.001,∗∗P < 0.01, ∗P < 0.05.
