Table 1.

Factors that increase or decrease levels of SHBG in women.

Factors that increase sex hormone binding gobulin	Factors that decrease sex hormone binding gobulin
Aging	Obesity
Infectious disease (HIV, Hepatitis C)	Diabetes, insulin resistance
Hyperthyrodism	Hypothyroidism
Hepatocellular dysfunction	Polycystic ovarian syndrome
Elevated estrogen	Hyperprolactinaemia
Medications (thiazolidines, anticonvulsants, oral contraceptives, selective estrogen receptor modulators)	Medications (glucocorticoids, tyrosine kinase, inhibitors, androgens)
Sex hormone binding polymorphisms	Hypercorticism
Extreme weight loss	Acromegaly
	Nephrotic syndrome