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. 2022 Nov 14;8(11):e11622. doi: 10.1016/j.heliyon.2022.e11622

Figure 5.

Figure 5

Acteoside reduces inflammatory mediators and adhesion molecules in serum and BALF of ALI mice. Before administration with CVF to induced ALI, mice were orally pretreated with different concentrations (100, 50, and 20 mg/kg/day) of acteoside or PDTC (100 mg/kg/day) or vehicle for 7 days. Serum and BALF were collected 1 h after CVF (35 μg/kg) i.v. injection for the ELISA detection. A–C: IL-6, TNF-α, and ICAM-1 levels in serum; D–F: IL-6, TNF-α, and ICAM-1 in BALF. Results were presented as mean ± SEM (n = 8). #P < 0.05 and ##P < 0.01 were compared with the control group; ∗P < 0.05 and ∗∗P < 0.01 were compared with the CVF group. ALI, acute injury lung; CVF, cobra venom factor; PDTC, pyrrolidinedithiocarbamic acid; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α; ICAM-1, intracellular adhesion molecule; SEM, standard error of the mean.