Table 1.

The function of mutp53 and the corresponding regulatory mechanisms.

Role	Tumor type	Target	Mechanism	Ref
Genetic instability	Osteosarcoma	Topoisomerase I	Promotes gene amplification	[67] [69]
		Mre11	Causes ineffective activation of ATM and genetic instability
	Lung cancer	Cyclin A, CHK1	Promotes proliferation of cells with genomic abnormalities	[70]
	Breast cancer	E2F4	Inhibits DNA damage repair	[71]
	Lung adenocarcinoma	Cell in cell	Causes abnormal mitosis and genomic instability	[72]
Ferroptosis	Lung cancer	SLC7A11	p53 3KR induces cell ferroptosis	[76]
			p534KR98]does not induce ferroptosis	[82]
	Oesophageal cancer	NRF2	Causes cell ferroptosis	[79]
Microenvironment	Colon cancer	TAM	Renders macrophages in a pro-tumor state	[92]
	NSCLS	ID4	Leads to tumor angiogenesis	[93]
	Leukemia	VEGF	Leads to tumor growth and metastasis	[94]
	Breast cancer	NF-κB	Causes an increased inflammatory response	[95]
	Colon adenocarcinoma	sIL-1Ra	Generates a pro-inflammatory tumor microenvironment	[96]
Stemness	Colon cancer	Lgr5, CD44	Promotes the expression of markers of CSCs	[99]
	Glioblastoma	WIP	Increases the expression of CSC-like markers	[100]
	Colorectal cancer	lncRNA	Enhances the stemness	[101]
	Breast cancer	MiR-200c	Promotes cancer stemness	[102]
	Lung adenocarcinoma	MiR-324-5p	Promotes cancer stemness	[103]
Clinical	Colorectal cancer	Bax, Bak, VDAC	Inhibits apoptosis of tumor cells	[105]
		EFNB2	Causes chemoresistance	[111]
	Osteosarcoma	Procaspase-3	Causes chemoresistance	[108]
	Colon cancer	PUMA	Causes chemoresistance	[109]
		p73	Inhibits apoptosis of tumor cells	[110]
		MDR1	Causes chemoresistance	[112]