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. 2022 Jul 9;42(7):1379–1391. doi: 10.1007/s10875-022-01325-2

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© The Author(s) 2022

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Fig. 2 — Characterization of circulating immune cell subsets in vaccinated and unvaccinated COVID-19 patients requiring hospitalization. (A) Absolute numbers of neutrophils (N), eosinophils (E), basophils (B), monocytes (M), and lymphocytes (L) in 36 vaccinated (blue dots) and 29 unvaccinated (red dots) COVID-19 patients requiring hospitalization. (B) Absolute numbers of plasmacytoid dendritic cells (pDCs), CD1c + dendritic cells and CD141 dendritic cells in 22 vaccinated (blue dots) and 17 unvaccinated (red dots) COVID-19 patients requiring hospitalization. (C) Mean Fluorescence Intensity of neutrophil activation markers (CD64, CD11b, and CD66b) and monocyte activation markers (CD64, CD11b, and HLA-DR) in 22 vaccinated (blue dots) and 17 unvaccinated (red dots) COVID-19 patients requiring hospitalization. (D) Frequency of CD14++ CD16- classical monocytes (M1), CD14 + CD16 + intermediate monocytes (M2), and CD14+ CD16++ non-classical monocytes (M3) in vaccinated (blue dots) and unvaccinated (red dots) COVID-19 patients requiring hospitalization. (E) Frequency of CD3+ T cells, CD19+ B cells, CD16+ NK cells, CD3+ CD56+ NKT cells, CD4+ T cells, and CD8+ T cells in 30 vaccinated (blue dots) and 26 unvaccinated (red dots) COVID-19 patients. (F) Frequency of plasmablasts in vaccinated (blue dots) and unvaccinated (red dots) COVID-19 patients requiring hospitalization. Black lines indicate mean values. *P < 0.05, ***P < 0.001 calculated with Mann–Whitney U test