Fig. 4.

Assessment of SARS-CoV-2 specific humoral and cellular response in survived and deceased COVID-19 patients. (A) Titers of anti-NIgGs and (B) anti-S IgMs in (n = 44) survivors and (n = 12) non-survivors, titers of (C) anti-S IgGs and (D) neutralizing antibodies in (n = 52) survivors and (n = 13) non-survivors among COVID-19 hospitalized patients. (E) Frequency of Spike-specific B cells in (n = 44) survivors and (n = 12) non-survivors among COVID-19 hospitalized patients. (F) Frequency of N and M-specific CD4 + T cells in (n = 35) survivors and (n = 12) non-survivors among COVID-19 hospitalized patients. (G) Frequency of S-specific CD4 + T cells in (n = 35) survivors and (n = 13) non-survivors among COVID-19 hospitalized patients. Blue and red dots correspond to vaccinated and unvaccinated individuals, respectively. Black lines indicate mean values. *P < 0.05; **P < 0.01 calculated with Mann–Whitney U test