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(A) A simplified model of core circadian clock transcriptional network. (B) Proposed transcriptional network of 12-hour oscillator. Please note while Ire1α mRNA exhibits an XBP1s-dependent 12-hour rhythms, XBP1s likely transcriptionally regulates the 12-hour rhythmic Ire1α expression via a yet-to-be-identified intermediate transcriptional factor, as ChIP-seq revealed no XBP1s recruitment to Ire1α gene promoter.
