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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Hepatology. 2023 Feb 17;77(3):1022–1035. doi: 10.1002/hep.32580

Figure 3. Mammalian 8-hour transcriptome and metabolome are prevalent.

Figure 3.

(A) Heat map of hepatic mRNA exhibiting dominant 8-hour oscillation ranked by phase. (B) GO analysis of top enriched KEGG pathways with p value and fold enrichment revealed by David analysis. (C) Heat map of hepatic metabolite exhibiting dominant 8-hour oscillation ranked by phase. (D) U2OS cells are transfected with different siRNAs and synchronized by dexamethasone. Distribution of periods of oscillations revealed by eigenvalue/pencil method under different condition (left) and representative level of thiamine and coenzyme A in cells with scrambled (black) or Cry1 (red) siRNAs.