EDS element mapping and point-scan element analysis of metallic nanoparticles in vivo. A, B. Intracellular metallic nanoparticles of the Co/Cr/Ti group, distributed as loose or needle-shaped/crystal-like agglomerates/aggregates. Circular nanoparticles were predominantly composed of Co (A1–2, A2–2, B2–2); needle-shaped agglomerates/aggregates were predominantly composed of Cr (A1–3); crystal-like agglomerates/aggregates were predominantly composed of Ti (B1–4, B2–4). C. Point scans of the three types of particles. Morphological features of the metallic nanoparticle aggregates corresponded to a predominant metal element; only a small percentage of other metals was present.