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. 2022 Nov 15;38:190–202. doi: 10.1016/j.jot.2022.05.005

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© 2022 Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Nrf2-siRNA blocked the protective effect of STE. The expressing levels of p65, Nrf2, and HO-1 were evaluated by western blotting (A) and quantified in (B) after Nrf2 knockdown. The expressing levels of MMP-13 and ADAMTS-4 (C, D). The expression level of NO, PGE2, IL-6, and TNF-α was determined via ELISA (E and F). Data were shown as mean ± SD. ##P < 0.01 compared to the control group; ∗∗P < 0.01 compared to the IL-1β alone stimulation group, n = 3.

Nrf2-siRNA blocked the protective effect of STE. The expressing levels of p65, Nrf2, and HO-1 were evaluated by western blotting (A) and quantified in (B) after Nrf2 knockdown. The expressing levels of MMP-13 and ADAMTS-4 (C, D). The expression level of NO, PGE2, IL-6, and TNF-α was determined via ELISA (E and F). Data were shown as mean ± SD. ##P < 0.01 compared to the control group; ∗∗P < 0.01 compared to the IL-1β alone stimulation group, n = 3.