Figure 3.

Prediction accuracy of single-source and multi-source polygenic prediction methods in simulations

(A and B) The proportion of causal variants in (A) is 0.1% and the proportion of causal variants in (B) is 1.0%. In each setting, three different cross-population genetic correlations (0.4, 0.7 and 1.0) were considered. Heritability was fixed at 50%. Prediction accuracy was measured by the squared correlation (R²) between the simulated and predicted phenotypes in the testing dataset, averaged across 20 simulation replicates. Error bar indicates the standard deviation of R² across simulation replicates.