Figure 4.

Comparison of previous and proposed liability-scale heritability estimates with 95% CI for 13 ICD-10 binary disease outcomes with $\le 3\text{\%}$ sample prevalence in the UK Biobank

Table 1 gives the full disease names, codes, sample prevalence, population prevalence, observed-scale estimates, and liability-scale conversions. We analyzed the 13 traits with our recently proposed GMRM software to obtain observed scale heritability estimates, accounting for marker effect size differences across SNPs of different minor allele frequency, linkage disequilibrium, and functional annotation in 382,390 unrelated UK Biobank individuals. We estimated the posterior mean observed scale heritability and plot the liability-scale estimates produced with either the classical expression of Equation 1 on the x axis or our proposed expressions of Equation 5 and Equation 10 on the y axis.