Figure 3.

Variants shared via Shariant over time

(A) Submission and sharing of unique variants per laboratory, presented as totals per organization over time (mm-dd-yy). Frequency of upload is dependent on the interpretation system in use by a laboratory (lab). The spike in submissions in November 2021 was due to the recent onboarding of organization 6. Organization 6 has only submitted one large batch of records, and this batch included historical data.

(B) Overall submissions of unique variants to Shariant over time and breakdown of variants submitted by one laboratory compared to variants submitted by multiple laboratories.

(C) Unique variants contributed by more than one laboratory with breakdown of comparison category: concordant-agreement variants, concordant-confidence variants, and discrepant variants. As of December 2021, concordant-agreement variants (n = 211) included those that were pathogenic, n = 145 (69%); likely pathogenic, n = 19 (9%); VUS, n = 37 (18%); likely benign, n = 9 (4%); and benign, n = 1 (0.5%). Concordant-confidence variants (n = 31) included those that were pathogenic or likely pathogenic, n = 30 (97%); and benign or likely benign, n = 1 (3%). Discrepant variants are detailed in Table 3.